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Synergistic Anti-Cancer Effect of Phenformin and Oxamate

Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide, recently recognized to have anti-cancer effec...

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Detalhes bibliográficos
Main Authors: Miskimins, W. Keith, Ahn, Hyun Joo, Kim, Ji Yeon, Ryu, Sun, Jung, Yuh-Seog, Choi, Joon Young
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897486/
https://ncbi.nlm.nih.gov/pubmed/24465604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085576
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