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SnoN activates p53 directly to regulate aging and tumorigenesis
We have identified SnoN as a direct activator of p53 to accelerate aging and inhibit tumorigenesis. SnoN has been shown previously to promote proliferation and transformation by antagonizing TGFβ signaling. We show that elimination of this TGFβ antagonistic activity of SnoN in vivo results in accele...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897278/ https://ncbi.nlm.nih.gov/pubmed/22805162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00857.x |
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