Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens

Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N-hydroxy-2-aminofluorene, are potent frameshift mutagens for Salmonella typhimurium. 2-Nitrosonaphthalene, 2-nitrosophenanthrene, 4-nitroso-trans-stilbene, 4-nitrosobiphenyl, and 4-nitrosoazo...

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Main Authors: Ames, Bruce N., Gurney, E. G., Miller, James A., Bartsch, H.
Format: Artigo
Jezik:Inglês
Izdano: 1972
Teme:
Biological Sciences: Genetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC389719/
https://ncbi.nlm.nih.gov/pubmed/4564203
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