NFκB induces overexpression of bovine FcRn: A novel mechanism that further contributes to the enhanced immune response in genetically modified animals carrying extra copies of FcRn

Among the many functions of the neonatal Fc receptor (FcRn) for IgG, it binds to IgG-opsonized antigen complexes and propagates their traffic into lysosomes where antigen processing occurs. We previously reported that transgenic (Tg) mice and rabbits that carry multiple copies and overexpress FcRn h...

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Detalhes bibliográficos
Main Authors: Cervenak, Judit, Doleschall, Márton, Bender, Balázs, Mayer, Balázs, Schneider, Zita, Doleschall, Zoltán, Zhao, Yaofeng, Bősze, Zsuzsanna, Hammarström, Lennart, Oster, Wolfgang, Kacskovics, Imre
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896600/
https://ncbi.nlm.nih.gov/pubmed/24492342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26507
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