Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae

Infantile-onset neuronal ceroid lipofuscinosis (INCL) is a severe pediatric neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein thioesterase 1 (Ppt1). This enzyme is responsible for the removal of a palmitate group from its substrate proteins, which may include pr...

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Autori principali: Aby, Elizabeth, Gumps, Katherine, Roth, Amalia, Sigmon, Stacey, Jenkins, Sarah E, Kim, Joyce J, Kramer, Nicholas J, Parfitt, Karen D, Korey, Christopher A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896500/
https://ncbi.nlm.nih.gov/pubmed/24091420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/fly.26630
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