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Cholesterol-free and cholesterol-bound Hedgehog: Two sparring-partners working hand in hand in the Drosophila wing disc?
Hedgehog (Hh) is a signaling ligand conserved from flies to humans that is covalently bound to both palmitate and cholesterol moieties. These lipid modifications are crucial for Hh signaling. A recent article reports that in both flies and human-cultured cells a cholesterol-free form of Hh (SHh-N*/H...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896491/ https://ncbi.nlm.nih.gov/pubmed/23892363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/fly.25655 |
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