Galectin-9 Enhances Cytokine Secretion, but Suppresses Survival and Degranulation, in Human Mast Cell Line

Galectin-9 (Gal-9), a lectin having a β-galactoside-binding domain, can induce apoptosis of Th1 cells by binding to TIM-3. In addition, Gal-9 inhibits IgE/Ag-mediated degranulation of mast cell/basophilic cell lines by binding to IgE, thus blocking IgE/Ag complex formation. However, the role of Gal-...

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Autori principali: Kojima, Reiji, Ohno, Tatsukuni, Iikura, Motoyasu, Niki, Toshiro, Hirashima, Mitsuomi, Iwaya, Keichi, Tsuda, Hitoshi, Nonoyama, Shigeaki, Matsuda, Akio, Saito, Hirohisa, Matsumoto, Kenji, Nakae, Susumu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896437/
https://ncbi.nlm.nih.gov/pubmed/24465902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086106
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