IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) i...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Keng-Mean, Hu, Wei, Troutman, Ty Dale, Jennings, Michelle, Brewer, Travis, Li, Xiaoxia, Nanda, Sambit, Cohen, Philip, Thomas, James A., Pasare, Chandrashekhar
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896167/
https://ncbi.nlm.nih.gov/pubmed/24379360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320294111
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