Φορτώνει......
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) i...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896167/ https://ncbi.nlm.nih.gov/pubmed/24379360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320294111 |
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