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A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer
Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53. In tumors with wild-type p53, there is often overexpression of MDM2 or MDM4 leading to functional inactivation of...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895963/ https://ncbi.nlm.nih.gov/pubmed/19762336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp224 |
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