A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer

Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53. In tumors with wild-type p53, there is often overexpression of MDM2 or MDM4 leading to functional inactivation of...

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Detalhes bibliográficos
Main Authors: Kulkarni, Diptee A., Vazquez, Alexei, Haffty, Bruce G., Bandera, Elisa V., Hu, Wenwei, Sun, Yvonne Y., Toppmeyer, Deborah L., Levine, Arnold J., Hirshfield, Kim M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Molecular Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895963/
https://ncbi.nlm.nih.gov/pubmed/19762336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp224
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