ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so...

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Detalhes bibliográficos
Main Authors: Matsuo, Hirotaka, Nakayama, Akiyoshi, Sakiyama, Masayuki, Chiba, Toshinori, Shimizu, Seiko, Kawamura, Yusuke, Nakashima, Hiroshi, Nakamura, Takahiro, Takada, Yuzo, Oikawa, Yuji, Takada, Tappei, Nakaoka, Hirofumi, Abe, Junko, Inoue, Hiroki, Wakai, Kenji, Kawai, Sayo, Guang, Yin, Nakagawa, Hiroko, Ito, Toshimitsu, Niwa, Kazuki, Yamamoto, Ken, Sakurai, Yutaka, Suzuki, Hiroshi, Hosoya, Tatsuo, Ichida, Kimiyoshi, Shimizu, Toru, Shinomiya, Nariyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895923/
https://ncbi.nlm.nih.gov/pubmed/24441388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03755
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