Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase.

Hyperacute rejection of a porcine organ by higher primates is initiated by the binding of xenoreactive natural antibodies of the recipient to blood vessels in the graft leading to complement activation. The majority of these antibodies recognize the carbohydrate structure Gal(alphal,3)Gal (gal epito...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sharma, A, Okabe, J, Birch, P, McClellan, S B, Martin, M J, Platt, J L, Logan, J S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7190
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