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A molecular brake controls the magnitude of long-term potentiation
Overexpression of suprachiasmatic nucleus circadian oscillatory protein (SCOP), a negative ERK regulator, blocks long-term memory encoding. Inhibition of calpain-mediated SCOP degradation also prevents the formation of long-term memory, suggesting rapid SCOP breakdown is necessary for memory encodin...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895372/ https://ncbi.nlm.nih.gov/pubmed/24394804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4051 |
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