Population Pharmacodynamic Modeling and Simulation of the Respiratory Effect of Acetazolamide in Decompensated COPD Patients

BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients may develop metabolic alkalosis during weaning from mechanical ventilation. Acetazolamide is one of the treatments used to reverse metabolic alkalosis. METHODS: 619 time-respiratory (minute ventilation, tidal volume and respiratory ra...

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Main Authors: Heming, Nicholas, Urien, Saïk, Fulda, Virginie, Meziani, Ferhat, Gacouin, Arnaud, Clavel, Marc, Planquette, Benjamin, Faisy, Christophe
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895035/
https://ncbi.nlm.nih.gov/pubmed/24466018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086313
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