Ceftriaxone Blocks the Polymerization of α-Synuclein and Exerts Neuroprotective Effects in Vitro

[Image: see text] The β-lactam antibiotic ceftriaxone was suggested as a therapeutic agent in several neurodegenerative disorders, either for its ability to counteract glutamate-mediated toxicity, as in cerebral ischemia, or for its ability to enhance the degradation of misfolded proteins, as in Ale...

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Hauptverfasser: Ruzza, Paolo, Siligardi, Giuliano, Hussain, Rohanah, Marchiani, Anna, Islami, Mehmet, Bubacco, Luigi, Delogu, Giovanna, Fabbri, Davide, Dettori, Maria A., Sechi, Mario, Pala, Nicolino, Spissu, Ylenia, Migheli, Rossana, Serra, Pier A., Sechi, GianPietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894726/
https://ncbi.nlm.nih.gov/pubmed/24099687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400149k
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