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Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogues

Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism. The carboxyltransferase (CT) domain of PC catalyzes the transfer of a carboxyl group from car...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lietzan, Adam D., St. Maurice, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894693/
https://ncbi.nlm.nih.gov/pubmed/24157795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.10.066
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