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Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogues
Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism. The carboxyltransferase (CT) domain of PC catalyzes the transfer of a carboxyl group from car...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3894693/ https://ncbi.nlm.nih.gov/pubmed/24157795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.10.066 |
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