OATP1B1-related drug–drug and drug–gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis

OBJECTIVE: Genetic variation in drug metabolizing enzymes and membrane transporters as well as concomitant drug therapy can modulate the beneficial and the deleterious effects of drugs. We investigated whether patients exhibiting rhabdomyolysis who were taking cerivastatin possess functional genetic...

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Main Authors: Tamraz, Bani, Fukushima, Hisayo, Wolfe, Alan R., Kaspera, Rüdiger, Totah, Rheem A., Floyd, James S., Ma, Benjamin, Chu, Catherine, Marciante, Kristin D., Heckbert, Susan R., Psaty, Bruce M., Kroetz, Deanna L., Kwok, Pui-Yan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894639/
https://ncbi.nlm.nih.gov/pubmed/23652407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283620c3b
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