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A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome
Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs,...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3894615/ https://ncbi.nlm.nih.gov/pubmed/20878717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20534 |
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