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Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case-Study in Lynch Syndrome
Genetic anticipation, described by earlier age of onset (AOO) and more aggressive symptoms in successive generations, is a phenomenon noted in certain hereditary diseases. Its extent may vary between families and/or between mutation sub-types known to be associated with the disease phenotype. In thi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176998/ https://ncbi.nlm.nih.gov/pubmed/21627626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1541-0420.2011.01607.x |
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