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Impact of age-associated increase in 2′-O-methylation of miRNAs on aging and neurodegeneration in Drosophila

MicroRNAs (miRNAs) are 20- to ∼24-nucleotide (nt) small RNAs that impact a variety of biological processes, from development to age-associated events. To study the role of miRNAs in aging, studies have profiled the levels of miRNAs with time. However, evidence suggests that miRNAs show heterogeneity...

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Main Authors: Abe, Masashi, Naqvi, Ammar, Hendriks, Gert-Jan, Feltzin, Virzhiniya, Zhu, Yongqing, Grigoriev, Andrey, Bonini, Nancy M.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894412/
https://ncbi.nlm.nih.gov/pubmed/24395246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.226654.113
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