Neuroprotective Role of the Basic Leucine Zipper Transcription Factor NFIL3 in Models of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons. Here we show that the basic leucine zipper transcription factor NFIL3 (also called E4BP4) confers neuroprotection in models of ALS. NFIL3 is up-regulated in primary neurons challenged with...

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Detalhes bibliográficos
Main Authors: Tamai, So-ichi, Imaizumi, Keisuke, Kurabayashi, Nobuhiro, Nguyen, Minh Dang, Abe, Takaya, Inoue, Masatoshi, Fukada, Yoshitaka, Sanada, Kamon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894342/
https://ncbi.nlm.nih.gov/pubmed/24280221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524389
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