Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

Islet function is incompletely understood in part because key steps in glutamate handling remain undetermined. The glutamate (excitatory amino acid) transporter 2 (EAAT2; Slc1a2) has been hypothesized to (a) provide islet cells with glutamate, (b) protect islet cells against high extracellular gluta...

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Detalhes bibliográficos
Main Authors: Zhou, Yun, Waanders, Leonie F., Holmseth, Silvia, Guo, Caiying, Berger, Urs V., Li, Yuchuan, Lehre, Anne-Catherine, Lehre, Knut P., Danbolt, Niels C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894318/
https://ncbi.nlm.nih.gov/pubmed/24280215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529065
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