Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA

Although highly homologous to other methylcytosine-binding domain (MBD) proteins, MBD3 does not selectively bind methylated DNA, and thus the functional role of MBD3 remains in question. To explore the structural basis of its binding properties and potential function, we characterized the solution s...

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Bibliographic Details
Main Authors: Cramer, Jason M., Scarsdale, J. Neel, Walavalkar, Ninad M., Buchwald, William A., Ginder, Gordon D., Williams, David C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894315/
https://ncbi.nlm.nih.gov/pubmed/24307175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512236
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