Pathophysiology of Hypercortisolism in Depression: Pituitary and Adrenal Responses to Low Glucocorticoid Feedback

OBJECTIVE: To test 3 theories of hypercortisolemia in depression – hypothalamic overdrive, impaired glucocorticoid feedback, or autonomous cortisol production. METHODS: We applied an overnight low cortisol feedback strategy by administering metyrapone to hypercortisolemic depressed inpatients and co...

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Bibliografiske detaljer
Main Authors: Carroll, Bernard J., Iranmanesh, Ali, Keenan, Daniel M., Cassidy, Frederick, Wilson, William H., Veldhuis, Johannes D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893569/
https://ncbi.nlm.nih.gov/pubmed/22211368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0447.2011.01821.x
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