Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

BACKGROUND: Chronic mucous hypersecretion (CMH) contributes to COPD exacerbations and increased risk for lung cancer. Because methylation of gene promoters in sputum has been shown to be associated with lung cancer risk, we tested whether such methylation was more common in persons with CMH. METHODS...

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Main Authors: Bruse, Shannon, Petersen, Hans, Weissfeld, Joel, Picchi, Maria, Willink, Randall, Do, Kieu, Siegfried, Jill, Belinsky, Steven A, Tesfaigzi, Yohannes
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893562/
https://ncbi.nlm.nih.gov/pubmed/24405663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-2
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