Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

Antzeko izenburuak

• The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.
  nork: Moroianu, J, et al.
  Argitaratua: (1996)
• RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153
  nork: Moroianu, Junona, et al.
  Argitaratua: (1997)
• Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.
  nork: Moroianu, J, et al.
  Argitaratua: (1995)
• Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.
  nork: Moroianu, J, et al.
  Argitaratua: (1995)
• Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.
  nork: Moroianu, J, et al.
  Argitaratua: (1995)