Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation

Megakaryocyte morphogenesis employs a “hypertrophy-like” developmental program, dependent on P-TEFb kinase activation and cytoskeletal remodeling. P-TEFb activation classically occurs by a feedback regulated process of signal-induced, reversible release of active Cdk9-cyclin T modules from large ina...

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Main Authors: Elagib, Kamaleldin E., Rubinstein, Jeremy D., Delehanty, Lorrie L., Ngoh, Valerie S., Greer, Peter A., Li, Shuran, Lee, Jae K., Li, Zhe, Orkin, Stuart H., Mihaylov, Ivailo S., Goldfarb, Adam N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892434/
https://ncbi.nlm.nih.gov/pubmed/24369834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.11.013
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