Cyclic AMP Signaling Inhibits Megakaryocytic Differentiation by Targeting Transcription Factor 3 (E2A) Cyclin-dependent Kinase Inhibitor 1A (CDKN1A) Transcriptional Axis

Signaling via the intracellular second messenger cyclic AMP (cAMP) has long been implicated in the repression of megakaryocytic differentiation. However, the mechanisms by which cAMP signaling impairs megakaryopoiesis have never been elucidated. In a human CD34(+) cell culture model, we show that th...

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Detaylı Bibliyografya
Asıl Yazarlar: Rubinstein, Jeremy D., Elagib, Kamaleldin E., Goldfarb, Adam N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Developmental Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365953/
https://ncbi.nlm.nih.gov/pubmed/22514271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366476
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