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Cyclic AMP Signaling Inhibits Megakaryocytic Differentiation by Targeting Transcription Factor 3 (E2A) Cyclin-dependent Kinase Inhibitor 1A (CDKN1A) Transcriptional Axis

Signaling via the intracellular second messenger cyclic AMP (cAMP) has long been implicated in the repression of megakaryocytic differentiation. However, the mechanisms by which cAMP signaling impairs megakaryopoiesis have never been elucidated. In a human CD34(+) cell culture model, we show that th...

詳細記述

保存先:
書誌詳細
主要な著者: Rubinstein, Jeremy D., Elagib, Kamaleldin E., Goldfarb, Adam N.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365953/
https://ncbi.nlm.nih.gov/pubmed/22514271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366476
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