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Intersubunit communication in the dihydroorotase–aspartate transcarbamoylase complex of Aquifex aeolicus

Aspartate transcarbamoylase and dihydroorotase, enzymes that catalyze the second and third step in de novo pyrimidine biosynthesis, are associated in dodecameric complexes in Aquifex aeolicus and many other organisms. The architecture of the dodecamer is ideally suited to channel the intermediate, c...

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Main Authors: Evans, Hedeel Guy, Fernando, Roshini, Vaishnav, Asmita, Kotichukkala, Mahalakshmi, Heyl, Deborah, Hachem, Fatme, Brunzelle, Joseph S, Edwards, Brian FP, Evans, David R
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892303/
https://ncbi.nlm.nih.gov/pubmed/24353170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2396
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