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Intersubunit communication in the dihydroorotase–aspartate transcarbamoylase complex of Aquifex aeolicus

Aspartate transcarbamoylase and dihydroorotase, enzymes that catalyze the second and third step in de novo pyrimidine biosynthesis, are associated in dodecameric complexes in Aquifex aeolicus and many other organisms. The architecture of the dodecamer is ideally suited to channel the intermediate, c...

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Autors principals: Evans, Hedeel Guy, Fernando, Roshini, Vaishnav, Asmita, Kotichukkala, Mahalakshmi, Heyl, Deborah, Hachem, Fatme, Brunzelle, Joseph S, Edwards, Brian FP, Evans, David R
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892303/
https://ncbi.nlm.nih.gov/pubmed/24353170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2396
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