Dihydroorotase from the Hyperthermophile Aquifiex aeolicus Is Activated by Stoichiometric Association with Aspartate Transcarbamoylase and Forms a One-Pot Reactor for Pyrimidine Biosynthesis(,)

In prokaryotes, the first three enzymes in pyrimidine biosynthesis, carbamoyl phosphate synthetase (CPS), aspartate transcarbamoylase (ATC), and dihydroorotase (DHO), are commonly expressed separately and either function independently (Escherichia coli) or associate into multifunctional complexes (A...

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Hlavní autoři: Zhang, Pengfei, Martin, Philip D., Purcarea, Cristina, Vaishnav, Asmita, Brunzelle, Joseph S., Fernando, Roshini, Guy-Evans, Hedeel I., Evans, David R., Edwards, Brian F. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863388/
https://ncbi.nlm.nih.gov/pubmed/19128030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801831r
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