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Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Chemical Agents Selective for Mutant or Normal Cultured Fibroblasts in Mixed and Heterozygote Cultures

Cultured fibroblasts established from skin biopsies from patients with the Lesch-Nyhan syndrome are deficient in hypoxanthine-guanine phosphoribosyl-transferase (EC 2.4.2.8) activity. This deficiency makes possible the use of chemicals that select either for or against deficient variants in cultured...

詳細記述

保存先:
書誌詳細
主要な著者: Fujimoto, Wilfred Y., Subak-Sharpe, John H., Seegmiller, J. Edwin
フォーマット: Artigo
言語:Inglês
出版事項: 1971
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC389230/
https://ncbi.nlm.nih.gov/pubmed/5283941
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