Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Chemical Agents Selective for Mutant or Normal Cultured Fibroblasts in Mixed and Heterozygote Cultures

Cultured fibroblasts established from skin biopsies from patients with the Lesch-Nyhan syndrome are deficient in hypoxanthine-guanine phosphoribosyl-transferase (EC 2.4.2.8) activity. This deficiency makes possible the use of chemicals that select either for or against deficient variants in cultured...

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Detalles Bibliográficos
Main Authors: Fujimoto, Wilfred Y., Subak-Sharpe, John H., Seegmiller, J. Edwin
Formato: Artigo
Idioma:Inglês
Publicado: 1971
Assuntos:
Biological Sciences: Genetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC389230/
https://ncbi.nlm.nih.gov/pubmed/5283941
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