Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis

BACKGROUND: Increased cellular iron levels are associated with high mortality in HIV-1 infection. Moreover iron is an important cofactor for viral replication, raising the question whether highly divergent lentiviruses actively modulate iron homeostasis. Here, we evaluated the effect on cellular iro...

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Detalhes bibliográficos
Main Authors: Koppensteiner, Herwig, Höhne, Kristin, Gondim, Marcos Vinicius, Gobert, Francois-Xavier, Widder, Miriam, Gundlach, Swantje, Heigele, Anke, Kirchhoff, Frank, Winkler, Michael, Benaroch, Philippe, Schindler, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892060/
https://ncbi.nlm.nih.gov/pubmed/24383984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-1
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