Critical Role in CXCR4 Signaling and Internalization of the Polypeptide Main Chain in the Amino Terminus of SDF-1α Probed by Novel N-Methylated Synthetically and Modularly Modified Chemokine Analogues

[Image: see text] The replication of human immunodeficiency virus type 1 (HIV-1) can be profoundly inhibited by the natural ligands of two major HIV-1 coreceptors, CXCR4 and CCR5. Stromal cell-derived factor-1α (SDF-1α) is a natural ligand of CXCR4. We have recently developed a synthetic biology app...

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מידע ביבליוגרפי
Main Authors: Dong, Chang-Zhi, Tian, Shaomin, Choi, Won-Tak, Kumar, Santhosh, Liu, Dongxiang, Xu, Yan, Han, Xiaofeng, Huang, Ziwei, An, Jing
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891921/
https://ncbi.nlm.nih.gov/pubmed/22779681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3003742
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