A Novel Synthetic Bivalent Ligand to Probe Chemokine Receptor CXCR4 Dimerization and Inhibit HIV-1 Entry

The chemokine receptor CXCR4 is one of two principal coreceptors for HIV-1 entry into target cells. CXCR4 is known to form homodimers. We previously demonstrated that the amino (N)-terminus of viral macrophage protein (vMIP)-II is the major determinant for CXCR4 recognition, and that V1 peptide deri...

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Detalhes bibliográficos
Main Authors: Choi, Won-Tak, Kumar, Santhosh, Madani, Navid, Han, Xiaofeng, Tian, Shaomin, Dong, Chang-Zhi, Liu, Dongxiang, Duggineni, Srinivas, Yuan, Jian, Sodroski, Joseph G., Huang, Ziwei, An, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476724/
https://ncbi.nlm.nih.gov/pubmed/22897429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2016712
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