Immunogenicity in mice and non-human primates of the Group A Streptococcal J8 peptide vaccine candidate conjugated to CRM197

Vaccine development for Group A streptococcal (GAS) infection has been extensively focused on the N-terminal hypervariable or the C-terminal conserved regions of the M protein, a major virulence factor of GAS. We evaluated the immunogenicity and functional activity of the conserved C-terminal peptid...

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Detalhes bibliográficos
Main Authors: Caro-Aguilar, Ivette, Ottinger, Elizabeth, Hepler, Robert W., Nahas, Deborah D., Wu, Chengwei, Good, Michael F., Batzloff, Michael, Joyce, Joseph G., Heinrichs, Jon H., Skinner, Julie M.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891704/
https://ncbi.nlm.nih.gov/pubmed/23249976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.23224
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