Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?

[Image: see text] Modulation of protein–protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with PPI target sites pose significant challenges to...

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Xehetasun bibliografikoak
Egile Nagusiak: Dias, David M., Van Molle, Inge, Baud, Matthias G. J., Galdeano, Carles, Geraldes, Carlos F. G. C., Ciulli, Alessio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2013
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891296/
https://ncbi.nlm.nih.gov/pubmed/24436777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400296c
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