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Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?
[Image: see text] Modulation of protein–protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with PPI target sites pose significant challenges to...
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| Główni autorzy: | , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2013
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891296/ https://ncbi.nlm.nih.gov/pubmed/24436777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400296c |
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