Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling

Cigarette smoking is a major risk factor for atherosclerosis and cardiovascular disease. CD36 mediates oxidized LDL (oxLDL) uptake and contributes to macrophage foam cell formation. We investigated a role for the CD36 pathway in nicotine-induced activation of macrophages and foam cell formation in v...

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Detalhes bibliográficos
Main Authors: Zhou, Ming-Sheng, Chadipiralla, Kiranmai, Mendez, Armando J., Jaimes, Edgar A., Silverstein, Roy L., Webster, Keith, Raij, Leopoldo
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891251/
https://ncbi.nlm.nih.gov/pubmed/23748423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00042.2013
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