Chenodeoxycholic acid stimulates Cl(−) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells

High levels of chenodeoxycholic acid (CDCA) and deoxycholic acid stimulate Cl(−) secretion in mammalian colonic epithelia. While different second messengers have been implicated in this action, the specific signaling pathway has not been fully delineated. Using human colon carcinoma T84 cells, we el...

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Hlavní autoři: Ao, Mei, Sarathy, Jayashree, Domingue, Jada, Alrefai, Waddah A., Rao, Mrinalini C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891218/
https://ncbi.nlm.nih.gov/pubmed/23761628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00416.2012
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