Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells

BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway through which NE induces MUC5AC gene expression in bronchial epithelial cells. ME...

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Detalhes bibliográficos
Main Authors: Song, Jeong-Sup, Cho, Kyung-Sook, Yoon, Hyung-Kyu, Moon, Hwa-Sik, Park, Sung-Hak
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Association of Internal Medicine 2005
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891072/
https://ncbi.nlm.nih.gov/pubmed/16491824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3904/kjim.2005.20.4.275
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