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miR-661 downregulates both Mdm2 and Mdm4 to activate p53
The p53 pathway is pivotal in tumor suppression. Cellular p53 activity is subject to tight regulation, in which the two related proteins Mdm2 and Mdm4 have major roles. The delicate interplay between the levels of Mdm2, Mdm4 and p53 is crucial for maintaining proper cellular homeostasis. microRNAs (...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890952/ https://ncbi.nlm.nih.gov/pubmed/24141721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.146 |
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