Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is attributed to an augmented response to genotoxic stress. We now report that GICs are primed to...

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Bibliografiska uppgifter
Huvudupphovsmän: Venere, M, Hamerlik, P, Wu, Q, Rasmussen, R D, Song, L A, Vasanji, A, Tenley, N, Flavahan, W A, Hjelmeland, A B, Bartek, J, Rich, J N
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
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Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890948/
https://ncbi.nlm.nih.gov/pubmed/24121277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.136
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