Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is attributed to an augmented response to genotoxic stress. We now report that GICs are primed to...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Venere, M, Hamerlik, P, Wu, Q, Rasmussen, R D, Song, L A, Vasanji, A, Tenley, N, Flavahan, W A, Hjelmeland, A B, Bartek, J, Rich, J N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890948/
https://ncbi.nlm.nih.gov/pubmed/24121277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.136
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados