Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is attributed to an augmented response to genotoxic stress. We now report that GICs are primed to...

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Bibliographische Detailangaben
Hauptverfasser: Venere, M, Hamerlik, P, Wu, Q, Rasmussen, R D, Song, L A, Vasanji, A, Tenley, N, Flavahan, W A, Hjelmeland, A B, Bartek, J, Rich, J N
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890948/
https://ncbi.nlm.nih.gov/pubmed/24121277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.136
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