Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

There is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting protein (RIP) kinase mediates necrosis and enhances inflammation in a...

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Detalles Bibliográficos
Autores principales: Murakami, Y, Matsumoto, H, Roh, M, Giani, A, Kataoka, K, Morizane, Y, Kayama, M, Thanos, A, Nakatake, S, Notomi, S, Hisatomi, T, Ikeda, Y, Ishibashi, T, Connor, K M, Miller, J W, Vavvas, D G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
Materias:
Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890945/
https://ncbi.nlm.nih.gov/pubmed/23954861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.109
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