Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Expression of receptor for hyaluronan-mediated motility (RHAMM), a breast cancer susceptibility gene, is tightly controlled in normal tissues but elevated in many tumors, contributing to tumorigenesis and metastases. However, how the expression of RHAMM is regulated remains elusive. Statins, inhibit...

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Bibliografiske detaljer
Main Authors: Wang, Zhongyuan, Wu, Yanping, Wang, Haifeng, Zhang, Yangqing, Mei, Lin, Fang, Xuexun, Zhang, Xudong, Zhang, Fang, Chen, Hongbo, Liu, Ying, Jiang, Yuyang, Sun, Shengnan, Zheng, Yi, Li, Na, Huang, Laiqiang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890879/
https://ncbi.nlm.nih.gov/pubmed/24367099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319190110
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