mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

A hypoxic microenvironment induces resistance to alkylating agents by activating targets in the mammalian target of rapamycin (mTOR) pathway. The molecular mechanisms involved in this mTOR-mediated hypoxia-induced chemoresistance, however, are unclear. Here we identify the mTOR target N-myc downstre...

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Detalhes bibliográficos
Main Authors: Weiler, Markus, Blaes, Jonas, Pusch, Stefan, Sahm, Felix, Czabanka, Marcus, Luger, Sebastian, Bunse, Lukas, Solecki, Gergely, Eichwald, Viktoria, Jugold, Manfred, Hodecker, Sibylle, Osswald, Matthias, Meisner, Christoph, Hielscher, Thomas, Rübmann, Petra, Pfenning, Philipp-Niklas, Ronellenfitsch, Michael, Kempf, Tore, Schnölzer, Martina, Abdollahi, Amir, Lang, Florian, Bendszus, Martin, von Deimling, Andreas, Winkler, Frank, Weller, Michael, Vajkoczy, Peter, Platten, Michael, Wick, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890826/
https://ncbi.nlm.nih.gov/pubmed/24367102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314469111
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