Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelial cells in vitro

PURPOSE: Retinal hypoxia-mediated activation of the hypoxia-inducible factor (HIF pathway) leading to angiogenesis is a major signaling mechanism underlying a number of sight-threatening diseases. Inhibiting this signaling mechanism with an already approved therapeutic molecule may have promising an...

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Autores principales: Vadlapatla, R K, Vadlapudi, A D, Pal, D, Mukherji, M, Mitra, A K
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
Materias:
Laboratory Study
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890766/
https://ncbi.nlm.nih.gov/pubmed/24202050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2013.240
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