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Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelial cells in vitro
PURPOSE: Retinal hypoxia-mediated activation of the hypoxia-inducible factor (HIF pathway) leading to angiogenesis is a major signaling mechanism underlying a number of sight-threatening diseases. Inhibiting this signaling mechanism with an already approved therapeutic molecule may have promising an...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890766/ https://ncbi.nlm.nih.gov/pubmed/24202050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2013.240 |
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