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Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
Smoothened (Smo) is a member of the Frizzled (FzD) class of G-protein-coupled-receptors (GPCRs), and functions as the key transducer in the Hedgehog (Hh) signalling pathway. Smo has an extracellular cysteine-rich domain (CRD), indispensable for its function and downstream Hh signalling. Despite its...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890372/ https://ncbi.nlm.nih.gov/pubmed/24351982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3965 |
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