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Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing

KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging to the proprotein convertase family of proteas...

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Xehetasun bibliografikoak
Egile Nagusiak: Harihar, Sitaram, Pounds, Keke M., Iwakuma, Tomoo, Seidah, Nabil G., Welch, Danny R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890299/
https://ncbi.nlm.nih.gov/pubmed/24454770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084958
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