Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing

KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging to the proprotein convertase family of proteas...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Harihar, Sitaram, Pounds, Keke M., Iwakuma, Tomoo, Seidah, Nabil G., Welch, Danny R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890299/
https://ncbi.nlm.nih.gov/pubmed/24454770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084958
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